Table 2. Overall Survival and High-Risk Factors for Patients with Stage II Colon Cancer.
| Factor | Patients, No. (events) | HR (95% CI) | P value |
|---|---|---|---|
| Patients with single high-risk factor (n = 318) | |||
| Age <50 y only | 62 (3) | 1 [Reference] | NA |
| <12 Nodes examined | 100 (17) | 3.64 (1.07-12.43) | .04 |
| Perforation or obstruction | 38 (6) | 3.15 (0.79-12.60) | .10 |
| Stage T4 disease | 67 (11) | 3.39 (0.95-12.16) | .06 |
| Vascular or perineural invasion only | 51 (4) | 1.49 (0.33-6.66) | .60 |
| All patients (N = 573) | |||
| Favorable high-risk factorsa | 132 (9) | 1 [Reference] | NA |
| Single unfavorable high-risk factorsb | 297 (46) | 2.40 (1.18-4.91) | .02 |
| Multiple high-risk factorsc | 143 (29) | 3.43 (1.62-7.25) | .001 |
Abbreviations: HR, hazard ratio; NA, not applicable.
a
Favorable high-risk factors were being younger than 50 years and/or having vascular or perineural invasion.
b
Single unfavorable high-risk factors were having fewer than 12 nodes examined, having perforation or obstruction, or having tumor stage 4.
c
This category included all combinations of high-risk factors combination.