Table 1.
Comparison of Two Unique Subsets of CD8+ Memory T Cells in Murine Skin
| Characteristic | TRM cells | sTCIRC cells |
|---|---|---|
| Steady state residency | Resident in skin | Transiently in skin |
| Markers in skin | CD69+CD103+ | CD69− |
| Requirement for TGF-β | Yes | Yes |
| Host defense to viral reinfection | Yes | Yes |
| Function for skin homeostasis | Yes | ? |
| Longevity | Yes | ? |
| Terminally differentiated | No? | No? |
Abbreviations: sTCIRC cell, skin-homing circulating memory T cell; TGF-β, transforming growth factor-β; TRM cell, resident memory T cell.