Table 3. Risk of Recurrent Stroke, Intracerebral Hemorrhage, and Death by Cerebral Microbleed Status.
| Characteristic | Recurrent stroke | Ischemic stroke | Intracerebral hemorrhage | All-cause mortality | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of events (rate)a | HR (95% CI) | aHRb (95% CI) | No. of events (rate)a | HR (95% CI) | aHR (95% CI) | No. of events (rate)a | HR (95% CI) | aHR (95% CI) | No. of events (rate)a | HR (95% CI) | aHR (95% CI) | |
| CMB presence | ||||||||||||
| None | 161 (5.0) | NA | NA | 153 (4.8) | NA | NA | 8 (0.2) | NA | NA | 39 (1.2) | NA | NA |
| CMB | 29 (7.7) | 1.51 (1.02-2.25) | 1.31 (0.87-1.98) | 26 (6.9) | 1.43 (0.94-2.16) | 1.26 (0.82-1.95) | 4 (1.0) | 4.18 (1.26-13.90) | 2.97 (0.85-10.43) | 10 (2.5) | 2.13 (1.06-4.26) | 1.87 (0.90-3.85) |
| CMB burden | ||||||||||||
| None | 161 (5.0) | NA | NA | 153 (4.8) | NA | NA | 8 (0.2) | NA | NA | 39 (1.2) | NA | NA |
| 1-2 | 12 (5.6) | 1.11 (0.62-2.00) | 0.95 (0.52-1.73) | 11 (5.2) | 1.07 (0.58-1.98) | 0.92 (0.49-1.72) | 1 (0.5) | 1.88 (0.23-14.99) | 1.59 (0.19-13.13) | 8 (3.6) | 3.05 (1.42-6.53) | 2.69 (1.23-5.91) |
| 3 or more | 8 (8.5) | 1.66 (0.82-3.38) | 1.29 (0.62-2.68) | 6 (6.4) | 1.31 (0.58-2.96) | 1.07 (0.46-2.48) | 3 (3.0) | 12.52 (3.32-47.22) | 6.08 (1.44-25.67) | 0 (0.0) | 0.00 (0.00) | 0.00 (0.00) |
| CMB topography | ||||||||||||
| None | 161 (5.0) | NA | NA | 153 (4.8) | NA | NA | 8 (0.2) | NA | NA | 39 (1.2) | NA | NA |
| Strictly deep/mixed | 17 (6.2) | 1.22 (0.74-2.01) | 1.01 (0.60-1.70) | 15 (5.5) | 1.13 (0.67-1.93) | 0.96 (0.56-1.67) | 3 (1.1) | 4.37 (1.16-16.48) | 2.79 (0.70-11.17) | 6 (2.1) | 1.77 (0.75-4.19) | 1.50 (0.61-3.67) |
| Strictly lobar | 12 (12.1) | 2.42 (1.34-4.34) | 2.30 (1.28-4.16) | 11 (11.1) | 2.33 (1.26-4.30) | 2.22 (1.20-4.11) | 1 (1.0) | 3.95 (0.49-31.61) | 3.93 (0.48-32.12) | 4 (3.8) | 3.22 (1.15-9.01) | 3.01 (1.07-8.50) |
Abbreviations: aHR, adjusted hazard ratio; CMB, cerebral microbleed; HR, hazard ratio; MRI, magnetic resonance imaging; NA, not applicable.
aEvent rates reported in 100 person-years.
bAdjusted hazard ratios for all outcomes adjusting for age, East Asian race/ethnicity, hypertension, chronic infarcts, and macrohemorrhages on MRI, and treatment assignment.