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. 2020 Oct 6;11:579628. doi: 10.3389/fimmu.2020.579628

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Copyright © 2020 Cui, Brady, Fulton, Zhang, Rosenbloom, Goldsmith, Moore and Popova

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TNF-α treatment of mesenchymal stromal cells reduces PDGFR-α expression. Human preterm lung mesehncymal stromal cells (MSCs) were cultured in serum free medium with or without 5 ng/ml TNF-α for 48 h. PDGFR-α mRNA and protein expression was assessed by qPCR and ELISA, respectively. Also assessed was the mRNA expression of WNT2, FOXF2, SPRY1, CCL2, and IL-6 mRNA expression. (A) TNF-α treatment significantly reduced mRNA expression of PDGFRA, WNT2, FOXF2, and SPRY1 and increased mRNA expression of CCL2 and IL-6. N = 6, one-way ANOVA. (B) TNF-α treatment significantly reduced PDGFR-α protein expression.