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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: J Neurosci Res. 2020 Apr 7;100(1):191–202. doi: 10.1002/jnr.24624

Fig. 1. Effects of systemic administration of BU10038 on nociceptive responses in nonhuman primates.

Fig. 1.

(A) Antinociception against acute noxious stimulus, 50°C water. (B) Antihypersensitivity against capsaicin-induced allodynia in 46°C water. (C) Comparison of antinociceptive duration of BU10038 (0.01 mg kg−1) and morphine (1.8 mg kg−1). (D) Comparison of antinociceptive potency of BU10038 and morphine. Each data point represents mean ± SEM (n = 4). All compounds were delivered subcutaneously. *P<0.05, significantly different from vehicle condition from the first time point to the corresponding time point. Reprinted with permission from Kiguchi et al. 2019.