Table II.

The one hundred most affected genes (by fold change) from microarray data for each drug were used as gene sets for analysis using the GO Resource Enrichment Analysis Tool. This analysis determines which GO terms are over- or under-represented using annotations for these gene sets. The table shows significant shared GO Biological Process terms used to describe each set of genes. These data reveal which cellular mechanisms may be hit by each drug.

Drug	GO Terms
Artesunate	Lipid droplet organization; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of neuron apoptotic process; cellular protein localization; negative regulation of gene expression; regulation of cellular metabolic process; regulation of primary metabolic process; regulation of nitrogen compound metabolic process.
Camptothecin	Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; intrinsic apoptotic signaling pathway in response to oxidative stress; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic mitochondrial changes; cellular response to UV; positive regulation of protein kinase B signalling; cellular response to starvation; positive regulation of protein kinase activity; regulation of cell population proliferation; regulation of response to stress.
Docetaxel	Cell division.
Gemcitabine	Mitotic chromosome movement towards spindle pole; meiotic sister chromatid cohesion, centromeric; spindle assembly involved in meiosis; mitotic metaphase plate congression; mitotic spindle assembly checkpoint; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; cellular response to amino acid starvation; positive regulation of cyclin-dependent protein kinase activity; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of mitotic spindle organization; centromere complex assembly; mitotic spindle organization; regulation of cytokinesis; G2/M transition of mitotic cell cycle; cellular response to UV; anaphase-promoting complex-dependent catabolic process; cell division; intrinsic apoptotic signaling pathway; regulation of G2/M transition of mitotic cell cycle; positive regulation of cellular catabolic process; DNA conformation change; positive regulation of cell population proliferation; regulation of apoptotic process.
Lenalidomide	N/A
Oxaliplatin	Response to corticosterone; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; intrinsic apoptotic signaling pathway; transcription initiation from RNA polymerase II promoter; cellular response to extracellular stimulus; regulation of neuron death; response to radiation; regulation of apoptotic signaling pathway; cell development; regulation of gene expression.

GO, gene ontology.