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. 2020 Sep 30;20(6):308. doi: 10.3892/ol.2020.12171

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Impact of MCM3 interacting proteins in HCC. (A) mRNA expression of MCM2, MCM5, CHK1 and DHX9 in HCC tissues and normal liver tissues from The Cancer Genome Atlas database. mRNA expression was normalized by RSEM. (B) Relative mRNA expression levels of MCM2, MCM5, CHK1 and DHX9 in HCC and adjacent tissues from the patients recruited in the present study. (C) OS curves and (D) RFS curves for HCC samples expressing high and low levels of the indicated MCM3 interacting proteins. MCM, minichromosome maintenance complex component; CHK1, checkpoint kinase 1; DHX9, DEAH (Asp-Glu-Ala-His) box helicase 9; HCC, hepatocellular carcinoma; RSEM, RNA-Seq by Expectation-Maximization; OS, overall survival; RFS, recurrence-free survival. *P<0.05, **P<0.01, ***P<0.001.