Table II.
Association between MCM3 expression levels and clinicopathologic characteristics in hepatocellular carcinoma in The Cancer Genome Atlas dataset (n=363).
| Clinical features | Cases, n | MCM3 levels (RSEM; mean ± SD) | P-value |
|---|---|---|---|
| Sample | |||
| LIHC | 363 | 10.7220±0.8776 | <0.001 |
| Normal | 50 | 9.3221±0.3847 | |
| Age at diagnosis, years | |||
| ≤45 | 48 | 10.9396±0.9240 | 0.065 |
| >45 | 314 | 10.6881±0.8683 | |
| Unknown | 1 | ||
| Sex | |||
| Female | 117 | 10.8264±0.8170 | 0.118 |
| Male | 246 | 10.6724±0.9024 | |
| AFP in serum, ng/ml | |||
| ≤20 | 143 | 10.4980±0.8607 | <0.001 |
| >20 | 129 | 10.9507±0.8032 | |
| Unknown | 91 | ||
| E-S grade | |||
| I–II | 225 | 10.5271±0.8640 | <0.001 |
| III–IV | 133 | 11.0550±0.8095 | |
| Unknown | 5 | ||
| Child-Pugh classification | |||
| A | 213 | 10.6595±0.8948 | 0.806 |
| B | 21 | 10.6102±0.6849 | |
| C | 1 | ||
| Unknown | 128 | ||
| Lymph node | |||
| N0 | 246 | 10.7852±0.8700 | 0.441 |
| N1 | 3 | 11.1746±0.4966 | |
| Unknown | 114 | ||
| Metastasis | |||
| M0 | 260 | 10.7999±0.8767 | 0.432 |
| M1 | 4 | 10.4529±0.7069 | |
| Unknown | 99 | ||
| HBsAg infection | |||
| Yes | 137 | 10.8366±0.9352 | |
| No | 0 | ||
| Unknown | 226 |
LIHC, liver hepatocellular carcinoma; RSEM, RNA-Seq by Expectation-Maximization; MCM3, minichromosome maintenance complex component 3; AFP, α-fetoprotein; E-S, pathological Edmondson-Steiner; HBsAg, hepatitis B surface antigen.