Table IV.
Association between MCM3 expression levels and clinicopathological characteristics in hepatocellular carcinoma (n=78).
| MCM3 levels | ||||
|---|---|---|---|---|
| Clinical features | Cases, n | Low/Negative, n (n=41) | High, n (n=37) | P-value |
| Age, years | ||||
| ≤45 | 31 | 17 | 14 | 0.819 |
| >45 | 47 | 24 | 23 | |
| Sex | ||||
| Male | 55 | 31 | 24 | 0.330 |
| Female | 23 | 10 | 13 | |
| Smoking | ||||
| Yes | 32 | 19 | 13 | 0.362 |
| No | 46 | 22 | 24 | |
| Drinking | ||||
| Yes | 36 | 19 | 17 | 1.000 |
| No | 42 | 22 | 20 | |
| HBsAg infection | ||||
| Yes | 54 | 28 | 26 | 1.000 |
| No | 24 | 13 | 11 | |
| AFP, ng/ml | ||||
| ≤20 | 26 | 14 | 12 | 1.000 |
| >20 | 52 | 27 | 25 | |
| ALT, U/l | ||||
| ≤40 | 41 | 23 | 18 | 0.650 |
| >40 | 37 | 18 | 19 | |
| AST, U/l | ||||
| ≤40 | 37 | 20 | 17 | 0.824 |
| >40 | 41 | 21 | 20 | |
| E-S grade | ||||
| I–II | 33 | 17 | 16 | 1.000 |
| III–IV | 45 | 24 | 21 | |
| Tumor size (cm) | ||||
| ≤5 | 32 | 18 | 14 | 0.649 |
| >5 | 46 | 23 | 23 | |
| Metastasis | ||||
| Yes | 25 | 14 | 11 | 0.809 |
| No | 53 | 27 | 26 | |
| Invasion | ||||
| Yes | 51 | 22 | 29 | 0.032 |
| No | 27 | 19 | 8 | |
MCM3, minichromosome maintenance complex component 3; HBsAg, hepatitis B surface antigen; AFP, α-fetoprotein; ALT, alanine aminotransferase; AST, aspartate transaminase; E-S, pathological Edmondson-Steiner.