Table V.
GO and KEGG pathway enrichment analyses of MCM3 and its node genes.
| Category | Pathway ID | Pathway description | Gene count | Matching proteins |
|---|---|---|---|---|
| Biological process | GO:0006260 | DNA replication | 10 | CDC45, CHK1, DHX9, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MCMBP |
| Biological process | GO:0006270 | DNA replication initiation | 7 | CDC45, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 |
| Biological process | GO:0006261 | DNA-dependent DNA replication | 8 | CDC45, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MCMBP |
| Biological process | GO:0000082 | G1/S transition of mitotic cell cycle | 7 | CDC45, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 |
| Biological process | GO:0032508 | DNA duplex unwinding | 6 | CDC45, DHX9, MCM2, MCM4, MCM6, MCM7 |
| Biological process | GO:0006268 | DNA unwinding involved in DNA replication | 4 | MCM2, MCM4, MCM6, MCM7 |
| Biological process | GO:0007049 | Cell cycle | 9 | CDC45, CHK1, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MCMBP |
| Biological process | GO:0022402 | Cell cycle process | 8 | CDC45, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MCMBP |
| Biological process | GO:0051276 | Chromosome organization | 8 | CDC45, CHK1, DHX9, MCM2, MCM4, MCM6, MCM7, MCMBP |
| Biological process | GO:0033044 | Regulation of chromosome organization | 3 | CDC45, CHK1, MCM2 |
| Biological process | GO:0006282 | Regulation of DNA repair | 2 | CHK1, DHX9 |
| Biological process | GO:0060968 | Regulation of gene silencing | 2 | CDC45, DHX9 |
| Biological process | GO:0031570 | DNA integrity checkpoint | 2 | CDC45, CHK1 |
| Biological process | GO:1902275 | Regulation of chromatin organization | 2 | CDC45, CHK1 |
| Cell component | GO:0042555 | MCM complex | 6 | MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 |
| Cell component | GO:0005654 | Nucleoplasm | 10 | CDC45, CHK1, DHX9, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MCMBP |
| Cell component | GO:0044427 | Chromosomal part | 7 | CDC45, CHK1, DHX9, MCM2, MCM3, MCM7, MCMBP |
| Cell component | GO:0000228 | Nuclear chromosome | 6 | CDC45, CHK1, DHX9, MCM2, MCM3, MCMBP |
| Cell component | GO:0000785 | Chromatin | 5 | CHK1, DHX9, MCM2, MCM7, MCMBP |
| Cell component | GO:0044454 | Nuclear chromosome part | 5 | CDC45, DHX9, MCM2, MCM3, MCMBP |
| Cell component | GO:0032991 | Protein-containing complex | 9 | CDC45, CHK1, DHX9, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 |
| Cell component | GO:0005813 | Centrosome | 4 | CDC45, CHK1, DHX9, MCM3 |
| Cell component | GO:0043596 | Nuclear replication fork | 2 | CDC45, MCM3 |
| Cell component | GO:0015630 | Microtubule cytoskeleton | 5 | CDC45, CHK1, DHX9, MCM2, MCM3 |
| Cell component | GO:0032993 | Protein-DNA complex | 2 | CDC45, MCM3 |
| Cell component | GO:0000790 | Nuclear chromatin | 2 | DHX9, MCMBP |
| Molecular function | GO:0004386 | Helicase activity | 8 | CDC45, DHX9, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 |
| Molecular function | GO:0003678 | DNA helicase activity | 5 | CDC45, DHX9, MCM4, MCM6, MCM7 |
| Molecular function | GO:0003688 | DNA replication origin binding | 4 | CDC45, DHX9, MCM2, MCM5 |
| Molecular function | GO:0003697 | Single-stranded DNA binding | 5 | CDC45, DHX9, MCM4, MCM6, MCM7 |
| Molecular function | GO:0005524 | ATP binding | 8 | CHK1, DHX9, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 |
| Molecular function | GO:0003677 | DNA binding | 8 | CDC45, DHX9, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 |
| Molecular function | GO:0043138 | 3′→5′ DNA helicase activity | 2 | CDC45, DHX9 |
| Molecular function | GO:1901363 | Heterocyclic compound binding | 9 | CDC45, CHK1, DHX9, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 |
| Molecular function | GO:0097159 | Organic cyclic compound binding | 9 | CDC45, CHK1, DHX9, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 |
| Molecular function | GO:0003824 | Catalytic activity | 9 | CDC45, CHK1, DHX9, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 |
| Molecular function | GO:0003682 | Chromatin binding | 3 | CDC45, DHX9, MCMBP |
| Molecular function | GO:0005488 | Binding | 10 | CDC45, CHK1, DHX9, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MCMBP |
| KEGG | hsa04110 | Cell cycle | 8 | CDC45, CHK1, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 |
| KEGG | hsa03030 | DNA replication | 6 | MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 |
GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; MCM, minichromosome maintenance complex component; CDC45, cell division control protein 45 homolog; CHK1, checkpoint kinase 1; DHX9, DEAH (Asp-Glu-Ala-His) box helicase 9; MCMBP, minichromosome maintenance complex binding protein.