Table VI.
Sensitivity and specificity of hepatocellular carcinoma diagnosis by analyzing the expression of MCM3 and its interacting proteins.
| Diagnostic marker | AUC | Sensitivity, % | Specificity, % |
|---|---|---|---|
| MCM2 | 0.930 | 85.95 | 88 |
| MCM3 | 0.932 | 85.40 | 92 |
| MCM5 | 0.895 | 74.93 | 92 |
| CHK1 | 0.883 | 75.76 | 90 |
| DHX9 | 0.727 | 52.34 | 96 |
| Model 1 (CHK1 and MCM3)a | 0.975 | 88.15 | 100 |
| Model 2 (DHX9 and MCM3)b | 0.967 | 99.17 | 94 |
| Model 3 (MCM2, MCM3 and MCM5)c | 0.989 | 98.35 | 94 |
a
Algorithm, Y=1.996× CHK1 + 3.174× MCM3 - 41.662
b
Algorithm, Y=−11.523× DHX9 + 10.173× MCM3 + 22.341
c
Algorithm, Y=−21.378× MCM5 + 3.841× MCM3 + 14.988× MCM2 + 49.305. MCM, minichromosome maintenance complex component; CHK1, checkpoint kinase 1; DHX9, DEAH (Asp-Glu-Ala-His) box helicase 9; AUC, area under the curve.