Table 6.
Clinicopathologic features of the kidneys
| Feature | Patients (n = 32) | Notes |
|---|---|---|
| Clinical findings | ||
| Diabetes/pre-diabetes | 20 (63%) | |
| Hypertension | 23 (72%) | |
| Obesity | 10 (31%) | |
| Acute kidney injury | 16 (53%) | n = 30a |
| Requiring renal replacement therapy | 5 (17%) | n = 30a |
| Creatinine, mg/dL | Range: 0.66–9.61 (n = 29) | Mean 1.7 |
| Proteinuria | 9 (50%) (n = 18) | None quantitated |
| Pathologic findings (n = 28)b | ||
| Diabetic nephropathy | 14 (50%) | |
| Diffuse mesangial glomerulosclerosis | 11 (39%) | |
| Nodular mesangial glomerulosclerosis | 3 (11%) | |
| Other diagnoses | ||
| Obesity related glomerulopathy | 2 | |
| Papillary Necrosis | 2 | |
| Thrombotic microangiopathy | 2 | |
| Atheroembolic disease | 1 | |
| Bilateral infarction | 1 | |
| Global glomerulosclerosis | 5–95% | Mean 22.7%b |
| Interstitial fibrosis and tubular atrophy | ||
| <25% | 16 (57%) | |
| 26–50% | 7 (25%) | |
| >50% | 5 (18%) | |
| Vascular sclerosis | ||
| Mild | 6 (21%) | |
| Moderate | 10 (36%) | |
| Severe | 12 (43%) | |
| C5b-9 immunohistochemical staining | ||
| Cases in arterioles | 67% | |
| Cases in glomeruli | 21% | |
a
Two ESRD patients excluded.
b
Excludes ESRD and chest only autopsies.