Figure 1.

Up-regulation of FABP7 expression in mutant hSOD1-linked mouse models. A, D and G) Western blot analysis of FABP7 expression in the lumbar spinal cord of age-matched non-transgenic (NonTG) and symptomatic hSOD1^G93A (G93A, about 140 days old) (A), or symptomatic hSOD1^H46R/H48Q (H46R/H48Q, about 210 days old) (D) or age-matched control hSOD1^WT mice (about 210 days old) (G). B, E and H) Quantification of FABP7 protein levels shown in A, D and G, respectively. FABP7 expression was quantified, normalized by the levels of a loading control and expressed as percentage of age-matched NonTG mice (each lane corresponds to a different animal, mean±S.D.). C, F and I) Fabp7 mRNA levels in the lumbar spinal cord of age-matched NonTG and symptomatic G93A (C), or symptomatic H46R/H48Q (F), or age-matched hSOD1^WT (I) mice. Fabp7 mRNA levels were determined by real-time PCR and corrected by Actin mRNA levels (n=3-4 mice, mean±S.D.).