Figure 2.

The role of IMiDs. IMiDs act in two different ways: they have an immunomodulating role and they also interfere with the tumor microenvironment. As regards immune modulation, the main actions are CD4⁺ and CD8⁺ T-cell costimulation, Th1 cytokine production, the reduction of inhibitory T-cell populations and boosting of NK cell function, antibody-dependent cellular cytotoxicity. IMiDs interfere with the tumor microenvironment: they have an antiangiogenetic role, anti-inflammatory properties and a direct anti-tumor effect.