Table 3. Enantioselective synthesis of spirocyclic β-hydroxy lactams.

Entry	Products		% yield	d.r. (b : c)	% ee a of b, c
1			94	50 : 50	55, 31
2			87	67 : 33	77, 32
3 b			91	78 : 22	89, 79
4			93	58 : 42	93, 69

^aDetermined by chiral SFC.

^bAcetic acid used as Brønsted acid.