Table 3. . Linear regression for assessing the hippocampal subfield volumes effect on the functional decline (determined by the difference between first and last available activities of daily living score) in Alzheimer’s disease patients during follow-up.
| Unadjusted model | ||||||||
|---|---|---|---|---|---|---|---|---|
| Left hemisphere | Right hemisphere | |||||||
| Hippocampal subfield volume | Estimation | SE | p-value | r2 | Estimation | SE | p-value | r2 |
| Hippocampal tail | 17.68 | 1821.1 | 0.9923 | 0.00% | -442.54 | 2194.6 | 0.841 | 0.08% |
| Subiculum | -1535.67 | 2045.9 | 0.4564 | 1.11% | -4185.94 | 2051.4 | 0.0466 | 7.69% |
| CA1 | -464.06 | 1354.6 | 0.7333 | 0.23% | -1968.28 | 1345 | 0.1496 | 4.11% |
| Hippocampal fissure | 556.66 | 3363.4 | 0.8692 | 0.05% | -2351.8 | 3334.4 | 0.4839 | 0.99% |
| Presubiculum | -925.53 | 2638.9 | 0.7273 | 0.25% | -2126.64 | 3218.9 | 0.5119 | 0.87% |
| Parasubiculum | -1682.52 | 9374.8 | 0.8583 | 0.06% | -7213.62 | 9432.7 | 0.448 | 1.16% |
| Molecular layer | -798.28 | 1688.8 | 0.6385 | 0.44% | -2570.09 | 1699.7 | 0.1368 | 4.37% |
| GC-DG | -1315.23 | 3222.1 | 0.6849 | 0.33% | -5179.31 | 3294.6 | 0.1222 | 4.71% |
| CA2-3 | -219.06 | 4300.9 | 0.9596 | 0.01% | -5673.39 | 4058.5 | 0.1683 | 3.76% |
| CA4 | -980.18 | 3636 | 0.7886 | 0.15% | -5046.23 | 3720.2 | 0.1811 | 3.55% |
| Fimbria | -5916.32 | 8494.9 | 0.4894 | 0.96% | -5419.63 | 8109.7 | 0.507 | 0.89% |
| HATA | -8542.31 | 12,946 | 0.5124 | 0.86% | -33,189.84 | 11,703.2 | 0.0066 | 13.86% |
| Adjusted model | ||||||||
| Left hemisphere | Right hemisphere | |||||||
| Hippocampal subfield volume | Estimation | SE | p-value | r2 | Estimation | SE | p-value | r2 |
| Hippocampal tail | -521.82 | 1734 | 0.7649 | 40.40% | 138.95 | 1909.4 | 0.9423 | 40.28% |
| Subiculum | -1543.87 | 1981.8 | 0.4402 | 41.10% | -2401.91 | 2052.5 | 0.2483 | 42.12% |
| CA1 | -226.82 | 1198.5 | 0.8508 | 40.32% | -226.82 | 1198.5 | 0.8508 | 40.32% |
| Hippocampal fissure | 584.72 | 3659.7 | 0.8738 | 40.31% | 10.63 | 3702.9 | 0.9977 | 40.27% |
| Presubiculum | 522.66 | 2474.9 | 0.8337 | 40.34% | 1298.14 | 3098.3 | 0.6773 | 40.52% |
| Parasubiculum | 3244.12 | 8497.5 | 0.7045 | 40.48% | 4857.55 | 8356.6 | 0.5641 | 40.74% |
| Molecular Layer | -798.28 | 1688.8 | 0.6385 | 0.44% | -798.28 | 1688.8 | 0.6385 | 0.44% |
| GC-DG | -1538.09 | 2997.9 | 0.6105 | 40.64% | -3644.11 | 3099.1 | 0.2461 | 42.13% |
| CA2-3 | -865.92 | 4031.6 | 0.8309 | 40.34% | -5404.07 | 3895.1 | 0.1725 | 42.83% |
| CA4 | -1372.56 | 3482.6 | 0.6954 | 40.49% | -3902.21 | 3554 | 0.2783 | 41.90% |
| Fimbria | -9564.96 | 7451.7 | 0.2062 | 42.48% | -5812.19 | 7147.1 | 0.4206 | 41.18% |
| HATA | -1225.42 | 12,988.8 | 0.9253 | 40.29% | -13,662.09 | 12,416.1 | 0.2773 | 41.91% |
p < 0.05 are printed in bold.
In the adjusted model Age, Sex, MMSE, CIRS, Site, NPI, and time between first and last measurements were included.
AD: Alzheimer’s disease; ADL: Activities of daily living; CA: Cornu ammonis; CIRS: Cumulative illness rating scale; GC-DG: Granule cells in dentate Gyrus; HATA: Hippocampal–amygdaloid transition area; MMSE: Mini-mental state examination; SE: Standard error.