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. 2020 Oct 19;11:80. doi: 10.1186/s13229-020-00391-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Effects of chronic treatment with rapamycin on TSC2 neuronal activity. Raster (upper panels) and ASDR plots (lower panels) of a single neuronal MEA culture at 60 DPP in the absence (A) and presence of rapamycin (10 nM) (B). Vertical-scale bar = 200 spikes per 200 ms bin. Underneath show changes in a basal excitability, b synchronised burst (SB) activity and the number of spikes in individual SB, c SB length and interval and d spikes firing outside of a SB. All plots show means ± SEM. *p < 0.05 following unpaired t tests. Number of recorded wells = 6