Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 19;11:80. doi: 10.1186/s13229-020-00391-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — Effects of AICAR and LYN-1604 on TSC2 neuronal activity. A Schematic to show the relationship of TORC1 to AMPK and ULK1. B Raster (upper panel) and ASDR (lower panel) plots of recordings of the same MEA showing 24-h exposure to AICAR (1 mM) and LYN-1604 (2 μM). C Gene expression analysis of the genes encoding GABAa2 (a) and GRIA1 (b) in control cells following 24-h exposure to LYN-1604 (2 μM). D Network activity following 24-h drug treatment of TSC2 neurons in the absence and presence of AICAR and LYN-1604 in the absence and presence of AICAR and LYN-1604 showing a basal excitability, b synchronised burst (SB) activity and the number of spikes in individual SBs, c SB length and interval and d, e the spikes out of SBs, presented as percentage of the response before the drugs treatment. E Correlation matrices heat map for TSC2 neurons in the absence and presence of LYN-1604, colours represent the correlation in the firing rates across the indicated electrode. Correlation matrices are calculated for 16 electrodes in control and TSC2 neurons plated on the MEAs. Values greater than zero represent positive correlation, while values below zero represent negative correlation. All plots show means ± SEM. *p < 0.05, **p < 0.01 following paired t-tests. Number of recorded wells = 7