Table 1.
Clinical parameters, interventions, and postmortem analysis results
| Treatment Group | ||||
| CsA | Anti-CD4 | Control group | Anti-Pan T-cell | |
| Clinical Parameters | ||||
| BW loss | 2/2 | 2/4 | 0/4 | 0/4 |
| Inappetence (hyporexia/anorexia) | 2/2 | 1/4 | 0/4 | 0/4 |
| Decreased fecal output | 2/2 | 1/4 | 0/4 | 0/4 |
| Lethargy | 2/2 | 1/4 | 0/4 | 0/4 |
| Max Temperature (+2 SD) | 2/2 | 2/4 | 2/4 | 2/4 |
| Max Temperature (+3 SD) | 2/2 | 2/4 | 1/4 | 2/4 |
| Interventions | ||||
| LRS SC fluids | 2/2 | 0/4 | 0/4 | 0/4 |
| Kale | 2/2 | 1/4 | 0/4 | 0/4 |
| Critical care/Diet Gel supplementation | 2/2 | 0/4 | 0/4 | 0/4 |
| Euthanized early (met humane endpoints) | 2/2 | 1/4 | 0/4 | 0/4 |
| Necropsy Parametersc | ||||
| Spleen weighta | 2.5g ± 0.9 | 2.7g ± 0.33 | 2.1g ± 0.5 | 2.75g ± 0.43 |
| Spleen weight, % of body weighta | 0.07% ± 0.025 | 0.06% ± 0.006 | 0.05% ± 0.009 | 0.07% ± 0.1 |
| Liver weighta | 122.55g ± 10.45 | 104.2g ± 10.6 | 104.5g ± 6.4 | 114.4g ± 10 |
| Liver weight, % of body weighta | 3.3% ± 0.23 | 2.6% ± 0.33 | 2.5% ± 0.15 | 2.7% ± 0.16 |
| Histology Parameters | ||||
| Liver | ||||
| Peri-portal inflammatory infiltrate | 2/2 | 3/4 | 3/4 | 4/4 |
| Spleen | ||||
| PALS depletion | 0/2 | 1/4 | 1/4 | 0/4 |
| Paramyloid in PALS | 0/2 | 1/4 | 2/4 | 2/4 |
| Mesenteric Lymph Node | ||||
| Lymphoid depletion | 1/2 | 2/3b | 2/4 | 1/4 |
| Follicle development | 1/2 | 1/3b | 2/4 | 2/4 |
BW, body weight; SD, standard deviation; SEM, standard error of the mean;
a
Values represent the mean ± SEM;
b
No lymph node identified for the fourth rabbit in this group;
c
Necropsy parameters are not considered significantly different via either one way ANOVA or paired t tests (P values range from 0.193–0.983).