Table 3.
Association of TERT and DPS with AAV in female and male individuals
| TERT rs2736100A | DSP rs2076295G | |||||
|---|---|---|---|---|---|---|
| n (AF) | P | OR (95% CI) | n (AF) | P | OR (95% CI) | |
| Female | ||||||
| MPA | 260 (0.677) | 0.0014 | 1.43 (1.15–1.78) | 198 (0.516) | 0.35 | 1.10 (0.90–1.36) |
| MPO-AAV | 358 (0.670) | 6.0 × 10−4 | 1.39 (1.15–1.67) | 269 (0.502) | 0.62 | 1.05 (0.88–1.25) |
| Controlsa | 3708 (0.595) | Referent | 3062 (0.491) | Referent | ||
| Male | ||||||
| MPA | 167 (0.679) | 0.049 | 1.32 (1.00–1.73) | 153 (0.622) | 2.3 × 10−5 | 1.76 (1.35–2.29) |
| MPO-AAV | 219 (0.668) | 0.064 | 1.25 (0.99–1.58) | 202 (0.616) | 3.5 × 10−6 | 1.71 (1.36–2.15) |
| Controlsa | 3003 (0.616) | Referent | 2355 (0.484) | Referent | ||
P values were calculated by chi-square test in comparison between each AAV subset and controls
AAV ANCA-associated vasculitis, MPA microscopic polyangiitis, MPO-AAV myeloperoxidase (MPO)-ANCA positive vasculitis, n allele count, AF allele frequency, OR odds ratio, 95% CI 95% confidence interval
aData in controls include allele data in healthy controls and 4.7KJPN obtained from the Japanese Multi Omics Reference Panel (jMorp) [22, 23]