Table 1.

Primary and secondary outcomes

Task	Cognitive domains and mood status assessments
Primary Outcomes
MMSE	Global Cognitive function
Digit Span	Attention, short term, and working memory
RAVLT	Verbal immediate memory
VR I & II	Non-verbal memory and visuospatial function
Digit symbol substitution	Psychomotor speed
POMS	Tension, depression, anger, vigor, esteem related affect, fatigue and confusion
Secondary Outcomes
Biomarkers	BDNF, Oxidative stress (LPO, MDA), Inflammatory markers (iNOS, COX2)
Biochemical blood profile	Lipid profile and blood glucose profile
fMRI	Brain activation at the dorsolateral prefrontal cortex

MMSE mini-mental state examination, RAVLT rey auditory verbal learning test, VR visual reproduction, POMS profile of mood state, BDNF brain-derived neurotrophic factor, LPO lipid hydroperoxides, MDA malondialdehyde, iNOS inducible nitric oxide synthase, COX2 cyclooxygenase 2, fMRI functional magnetic resonance imaging