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[Preprint]. 2020 Oct 15:2020.10.13.20211664. [Version 1] doi: 10.1101/2020.10.13.20211664

Figure 4: IgM deposition on endothelium in COVID-19 lung.

Figure 4:

Lung paraffin sections from two autopsy patients (lung A, upper panels; lung B, lower panels) were stained with hematoxylin and eosin (A & C) or with an anti-IgM antibody (B & D). A: A section of the left upper lobe of the lung shows a widened interstitium with capillaries showing reactive endothelium (thick arrow). There are hyaline membranes lining alveolar spaces (thin arrow), consistent with the exudative phase of diffuse alveolar damage (acute lung injury). B: Anti-IgM immunohistochemical staining of the same tissue highlights capillary endothelium in that area. C: A small artery of a bronchiole stained with hematoxylin and eosin, with (D) endothelial staining for anti-IgM. Size bars represent 50 microns.