Table 3: Summary of identified proteins associated with chemical compounds in ChEMBL25, IUPHAR/BPS Guide to Pharmacology, Pharos, or ZINC.
For each human protein, we show RNA-seq experimental evidence (‘Bu’ for bulk, ‘Sc’ for single-cell, and ‘Both’ for bulk and single-cell), whether or not it is a known SARS-CoV-2 and if there are any approved drugs for each target, respectively.
| Gene name | RNA-seq | SARS-CoV-2 interactor? | Approved drugs? |
|---|---|---|---|
| ATR | Bu | Y | N |
| BRCA1 | Bu | N | N |
| CSNK2B | Bu | Y | N |
| HSF1 | Bu | N | N |
| NFE2L2 | Bu | Y | N |
| OAT | Bu | Y | N |
| PLAU | Bu | Y | Y |
| UBE2I | Bu | N | N |
| CREB1 | Sc | N | N |
| CREBBP | Sc | N | N |
| CSNK2A1 | Sc | N | N |
| CSNK2A2 | Sc | Y | N |
| EGFR | Sc | N | Y |
| ESRRA | Sc | N | Y |
| HES1 | Sc | N | N |
| HNF4A | Sc | N | N |
| HSPA8 | Sc | N | N |
| IRAK1 | Sc | Y | Y |
| JAK2 | Sc | Y | Y |
| NEU1 | Sc | Y | N |
| NR1H3 | Sc | N | N |
| NR3C1 | Sc | N | Y |
| RELA | Sc | N | Y |
| RXRA | Sc | N | Y |
| ACAT1 | Both | Y | N |
| ATM | Both | Y | N |
| BRD2 | Both | Y | N |
| EP300 | Both | N | N |
| ERBB2 | Both | Y | Y |
| JUN | Both | N | N |
| MYC | Both | N | N |
| STAT6 | Both | Y | N |