Table 3.
Univariate and multivariate analyses of factors related to recurrence
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| p value | HR | 95%CI | p value | HR | 95%CI | |
| Age (years) | 0.520 | 1.008 | 0.983–1.034 | |||
| Sex (female) | 0.878 | 1.036 | 0.660–1.627 | |||
| Etiology (HCV) | 0.004 | 2.426 | 1.334–4.411 | 0.006 | 2.438 | 1.293–4.599 |
| Child–Pugh class (A) | 0.007 | 0.492 | 0.294–0.823 | 0.042 | 0.524 | 0.281–0.976 |
| Platelets (×104/μL) | 0.742 | 0.994 | 0.957–1.031 | |||
| ALT (IU/L) | 0.048 | 1.006 | 1.000–1.012 | 0.873 | 1.001 | 0.993–1.008 |
| Hyaluronic acid (ng/mL) | < 0.001 | 1.001 | 1.001–1.002 | 0.575 | 1.000 | 0.999–1.001 |
| Type IV collagen 7S (ng/mL) | 0.000 | 1.146 | 1.073–1.224 | 0.130 | 1.080 | 0.978–1.192 |
| Tumor size (mm) | 0.037 | 1.040 | 1.002–1.079 | 0.573 | 1.012 | 0.971–1.054 |
| Number of tumors | < 0.001 | 2.172 | 1.459–3.235 | 0.005 | 1.930 | 1.219–3.057 |
| AFP (ng/mL) | 0.120 | 1.001 | 1.000–1.001 | |||
| AFP-L3 (> 15%) | 0.084 | 1.725 | 0.929–3.205 | |||
| DCP (mAU/mL) | 0.282 | 1.000 | 1.000–1.000 | |||
| PET positive | 0.021 | 2.425 | 1.144–5.138 | 0.112 | 1.969 | 0.854–4.540 |
HR hazard ratio, CI confidence interval, HCV hepatitis C virus, ALT alanine aminotransferase, HCC hepatocellular carcinoma, AFP alpha-fetoprotein, AFP-L3 Lens culinaris agglutinin-reactive alpha-fetoprotein, DCP, Des-gamma-carboxyprothrombin, PET positron emission tomography