Table 1.

Mean sieving coefficient and daily loss of amino acids, vitamins and trace elements

Nutrient	Molecular weight [g/mol]	Mean SCa ± SE	95% CI	Daily lossb [mg]	Standardized daily lossc [mg]
Alanine	89.1	1.02 ± 0.03	0.95–1.09	1102.3 ± 98.4	603.7 ± 37.2
Arginine	174.2	0.99 ± 0.04	0.91–1.07	427.9 ± 42.4	237.6 ± 16.3
Aspartic acid	133.1	0.82 ± 0.07	0.67–0.97	32.9 ± 2.3	20.3 ± 1.9
Citrulline	175.2	0.93 ± 0.05	0.82–1.03	756.0 ± 45.3*	439.4 ± 24.9*
Glutamic acid	147.1	0.53 ± 0.03	0.47–0.60	208.71 ± 17.3	118.4 ± 7.4
Glutamine	146.2	0.96 ± 0.03	0.90–1.01	2525.9 ± 172.8	1397.3 ± 68.1
Glycine	75.1	0.89 ± 0.03	0.82–0.96	558.1 ± 39.8	317.4 ± 20.1
Histidine	155.2	0.83 ± 0.02	0.78–0.87	387.9 ± 27.7	216.4 ± 12.1
Hydroxyproline	131.1	6.63 ± 0.83	4.94–8.31	224.7 ± 28.6	131.3 ± 18.5
Isoleucine	131.2	0.94 ± 0.02	0.89–0.99	373.9 ± 35.2	206.9 ± 13.1
Leucine	131.2	0.81 ± 0.02	0.76–0.86	592.5 ± 57.8	330.2 ± 21.9
Lysine	146.2	0.88 ± 0.03	0.83–0.94	968.1 ± 90.3	535.4 ± 38.6
Methionine	149.2	0.90 ± 0.03	0.83–0.97	182.5 ± 19.4	100.0 ± 8.1
Ornithine	132.2	0.70 ± 0.02	0.66–0.74	291.1 ± 28.5	161.4 ± 11.2
Phenylalanine	165.2	0.91 ± 0.03	0.85–0.96	626.1 ± 57.8	349.6 ± 25.1
Proline	115.1	0.75 ± 0.02	0.71–0.79	558.4 ± 47.7	308.0 ± 21.4
Serine	105.1	0.96 ± 0.04	0.88–1.04	339.3 ± 24.4	196.8 ± 9.9
Taurine	125.2	0.77 ± 0.08	0.62–0.93	124.4 ± 2.2	71.1 ± 12
Threonine	119.1	1.00 ± 0.03	0.95–1.06	496.8 ± 43.7	276.4 ± 20.0
Tryptophan	204.2	0.55 ± 0.03	0.49–0.61	128.1 ± 11.9	72.8 ± 4.9
Tyrosine	181.2	0.96 ± 0.02	0.91–1.01	554.5 ± 51.9	307.3 ± 20.9
Valine	117.1	0.88 ± 0.02	0.84–0.93	895.5 ± 81.7	499.4 ± 29.6
Carnitine	161.2	0.92 ± 0.04	0.83–1.01	1698.0 ± 134.7*	981.9 ± 75.8*
Vitamin B1	265.4	UD	UD	UD	UD
Vitamin B6	169.2	UD	UD	UD	UD
Vitamin B12	1355.4	UD	UD	UD	UD
Vitamin C	176.1	0.83 ± 0.07	0.69–0.98	100.5 ± 15.3	59.0 ± 9.2
Vitamin D2	397	UD	UD	UD	UD
Vitamin D3	384.6	UD	UD	UD	UD
Copper	63.6	0.009 ± 0.002	0.006–0.013	0.33 ± 0.05	0.20 ± 0.03
Iron	55.8	0.02 ± 0.01	0–0.04	0.07 ± 0.02	0.04 ± 0.09
Folate	441.4	0.51 ± 0.03	0.44–0.58	59.9 ± 11.7**	35.3 ± 6.9**
Selenium	79.0	0.036 ± 0.02	0–0.08	0.04 ± 0.01	0.04 ± 0.02
Zinc	65.4	0.10 ± 0.07	0–0.24	0.67 ± 0.20	0.64 ± 0.32

^*µmol/day **µg/day

SC sieving coefficient, SE standard error, CI confidence interval, UD undetected

^aSC was calculated as $\frac{\left[C_{\text{eff}}\right]}{\left[C_{\text{pl}}\right]}$, where C_eff is effluent concentration and C_pl is plasma concentration

^bDaily loss (mg) was calculated by C_pl × SC × effluent volume per 24 h

^cStandardized daily loss (mg) was estimated for CRRT dose 25 mL/kg/h for 24 h