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. 2019 Dec 19;15(6-7):646–663. doi: 10.1080/15592294.2019.1700628

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 6. — a) MET and HGF expression levels among different brain regions and whole blood. b) Genomic context of the most significant CpG site associated with the depressive phenotype in the longitudinal analyses. Genomic positions of RefSeq genes are displayed in the bottom part and indicated by arrows. The position of the significant CpG site is highlighted by black lines. Since analyses were performed based on data obtained in blood, chromatin marks overlapping in brain and blood cells were investigated. Chromatin states of eight tissues downloaded from the 37/hg19 WashU Epigenome Browser are illustrated. Each functional role of a segment is indicated by a particular colour. BrainAC: brain anterior caudate; BrainCG: brain cingulate gyrus; BrainHIPPO: brain hippocampus; BrainITL: brain inferior temporal lobe; BrainDPC: brain dorsolateral prefrontal cortex; BrainSN: brain substantia nigra; BrainAG: brain angular gyrus; PBMC: peripheral blood mononuclear primary cells.