Fig. 3.

Regional interactions between amyloid- and tau-PET on FDG-PET metabolism in MCI. a Projection of significant clusters resulting from the voxel-wise analysis. b Scatterplots are based on mean SUVR values extracted from voxel-wise analyses for each of the significant clusters (arranged by anatomical adjacency). For all statistical analyses, amyloid-PET was used as a continuous measure; for illustrational purposes, however, amyloid levels were binarized into high and low levels (median split). Scatterplots are presented after removal of outliers (i.e., defined as influential observations by Cook’s distance and 3 standard deviations from the mean); for regression plots including the outliers, see supplementary Fig. 1