Fig. 5.

Effect of FMT in SKG mice. The effect of FMT on alveolar bone destruction was determined. In this experiment, Pg W83 strain was used. ABL of the upper jaw in each group was measured (a). AS was measured every week after FMT and LA i.p. injection (b). Representative figures of hind paws in four groups showing joint inflammation (c LA-FMT, d Pg/LA-FMT). H&E staining of joint tissue sections (e LA-FMT, f Pg/LA-FMT). Original magnification; scale bar 500 μm. To evaluate intestinal inflammation 6 weeks after FMT, IL-6 production in joint and intestinal tissues of SKG mice was measured by ELISA (g–i). To assess CP synthesis, ELISA was performed in the joint tissues (j), small intestines (k), and large intestines (l). Data represent mean ± SD (b, c, and h–m) of 6 mice per group. Statistical analyses were performed using the Tukey-Kramer test and Bonferroni-corrected Mann-Whitney U test for multiple comparisons (*P < 0.05, **P < 0.01)