Table 2.
The number of synergistic and antagonistic combination with clarithromycin and each antimicrobial
| CLR/AMK | CLR/IPM | CLR/MXF | |||
|---|---|---|---|---|---|
| Species | Categories of FIC index | N (%, Adjusted residual) | p value | ||
| M.abscessus complex | Synergy + Additive | 5 (17.2, − 1.5) | 14 (48.3, 3.1**) | 5 (17.2, − 1.5) | 0.001** |
| N = 29† | Indifference + Antagonism | 24 (82.8, 1.5) | 15 (51.7, − 3.1**) | 24 (82.8, 1.5) | |
| M. abscessus subsp. massiliense | Synergy + Additive | 3 (16.7, −1.3) | 9 (50.0, 2.6**) | 3 (16.7, − 1.3) | 0.036* |
| N = 18 | Indifference + Antagonism | 15 (83.3, 1.3) | 9 (50.0, −2.6**) | 15 (83.3, 1.3) | |
| M. abscessus subsp. abscessus | Synergy + Additive | 2 (20.0, −0.8) | 5 (50.0, 1.7) | 2 (20.0, −0.8) | 0.24 |
| N = 10 | Indifference + Antagonism | 8 (80.0, 0.8) | 5 (50.0, −1.7) | 8 (80.0, 0.8) | |
† including M. abscessus subsp. boletii (n = 1)
* p value < 0.05, ** p value < 0.01
* adjusted residuals > |1.96|, ** adjusted residuals > |2.58|
Abbreviations: FIC index fractional inhibitory concentration index, CLR clarithromycin, AMK amikacin, IPM imipenem, MXF moxifloxacin