Table 3.
The number of synergistic and antagonistic combination with clarithromycin and imipenem in each clinical status
| FIC index | |||
|---|---|---|---|
| Synergy + Additive N = 14 (%) |
Indifference + Antagonism N = 15 (%) |
p value | |
| Age | |||
| < 65 years | 7 (24.1) | 7 (24.1) | 0.86 |
| ≥65 years | 7 (24.1) | 8 (27.6) | |
| Sex | |||
| Male | 6 (20.7) | 6 (20.7) | 0.88 |
| Female | 8 (27.6) | 9 (31.0) | |
| Smoking history | |||
| Yes | 3 (10.3) | 6 (20.7) | 0.43 |
| No | 11 (37.9) | 9 (31.0) | |
| With bronchiectasis | |||
| Yes | 4 (13.8) | 6 (20.7) | 0.70 |
| No | 10 (34.5) | 9 (31.0) | |
| With immunosuppression | |||
| Yes | 10 (34.5) | 5 (17.2) | 0.040* |
| No | 4 (13.8) | 10 (34.5) | |
| Pretreatment of antibiotics | |||
| Yes | 6 (20.7) | 8 (27.6) | 0.57 |
| No | 8 (27.6) | 7 (24.1) | |
| erm (41) gene status | |||
| del + C28 | 10 (34.5) | 10 (34.5) | 0.78 |
| T28 | 4 (13.8) | 5 (17.2) | |
Antibiotics including clarithromycin (n = 3)
p value < 0.05, ** p value < 0.01
Abbreviations: FIC index fractional inhibitory concentration index, del deletion