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. 2020 Oct 6;10:570025. doi: 10.3389/fcimb.2020.570025

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Copyright © 2020 Wolfarth, Smith, VanInsberghe, Dunlop, Neish, Corwin and Jones.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pregnancy outcomes in human microbiota-associated (HMA) mice harboring the microbiota collected from the vaginal tract of pregnant women with bacterial vaginosis. (A) The number of pups detected in the uterine horns of HMA mice on 18.5 dpc separated by the Nugent score of the corresponding donor. Data graphed as mean ± SEM. (B) Shannon diversity index of the mouse vaginal microbiota determined via 16S analysis on 18.5 dpc separated by litter size of the pregnant HMA mouse. Less than 7 pups on 18.5 dpc is considered a small litter, while 7 or more pups is considered a large litter. Data graphed as mean ± SEM. (C) Principal Component Analysis (PCA) plot depicting the beta-diversity of the microbiota community structure within the vaginal tract of HMA mice on 18.5 dpc. Symbols are colored by the litter size on 18.5 dpc.