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. 2020 Oct 6;10:570025. doi: 10.3389/fcimb.2020.570025

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Copyright © 2020 Wolfarth, Smith, VanInsberghe, Dunlop, Neish, Corwin and Jones.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pregnancy outcome in human microbiota-associated (HMA) mice is associated with altered uterine cytokine levels during pregnancy. (A) Cytokine concentrations in the uterus of HMA mice on 18.5 dpc. Cytokine levels are plotted with respect to the litter size. Statistical significance determined using linear regression analysis, p-value is indicated on the figure for each cytokine. (B) Principal Component Analysis (PCA) analysis depicting the correlation between cytokines concentrations in the uterus that were significantly altered or trending toward significance in (A), the HMA mouse vaginal microbiota community, and the Nugent score of the corresponding donor patient.