Fig. 1.

IKZF1 mutation in AML. a The frequency of IKZF1 mutation in our AML cohort and literature reports. b The type of IKZF1 mutation identified in our cohort and literature reports. c Genetic lesion in AML with IKZF1 mutation. d The frequency of PTPN11, SF3B1, bi-allele CEBPA and WT1 mutations in IKZF1^mut-AML and IKZF1^wt-AML from our cohort, respectively. e The frequency of IKZF1 mutation in PTPN11, SF3B1, bi-allele CEBPA, WT1-wild type/-mutated AML from our cohort, respectively. f The statistical significance of associations between IKZF1 and other gene mutations in our study was assessed by Chi-square test with continuity correction. Odds ratio was also calculated to define whether the correlation was positive or negative. g The frequency of SF3B1, FLT3, EZH2, KRAS, BCOR and DNMT3A mutations in IKZF1^mut-AML and IKZF1^wt-AML from OHSU study, respectively. h The frequency of IKZF1 mutation in SF3B1, FLT3, EZH2, KRAS, BCOR and DNMT3A-wild type/-mutated AML from OHSU study, respectively. i Associations between IKZF1 and other gene mutations in OHSU study were also analyzed as f indicated. NS, P ≥ 0.05; *, P < 0.05; **, P < 0.01; ***, P < 0.001