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. 2020 Oct 20;21:100461. doi: 10.1016/j.imu.2020.100461

Table 2.

The binding energies (kcal/mol) of selected nucleotide-analog inhibitors docked onto SARS-CoV-2 RdRp (6M71).

Ligand Nucleoside Binding energy
ATPa −52.12
Remdesivir-TP A −58.94
Favipiravir-TP A,G −45.72
Galidesivir-TP A −42.47
GS-4611203 U,T −36.50
Aphidicolin C −41.45
Combivir T −38.98
Didanosine A −38.05
Zalcitabine C −37.62
Stavudine T −31.74
Lamivudine-TP C −47.54
Carbovir-TP G −49.63
(−)FTC-TP C −37.42
a

ATP is the substrate.