Table 2.
The binding energies (kcal/mol) of selected nucleotide-analog inhibitors docked onto SARS-CoV-2 RdRp (6M71).
| Ligand | Nucleoside | Binding energy |
|---|---|---|
| ATPa | −52.12 | |
| Remdesivir-TP | A | −58.94 |
| Favipiravir-TP | A,G | −45.72 |
| Galidesivir-TP | A | −42.47 |
| GS-4611203 | U,T | −36.50 |
| Aphidicolin | C | −41.45 |
| Combivir | T | −38.98 |
| Didanosine | A | −38.05 |
| Zalcitabine | C | −37.62 |
| Stavudine | T | −31.74 |
| Lamivudine-TP | C | −47.54 |
| Carbovir-TP | G | −49.63 |
| (−)FTC-TP | C | −37.42 |
ATP is the substrate.