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The interaction between ZTP and the N-terminal domain (NTD). (A) RMSF analysis of the NTD. RMSF of the N-protein is shown alongside the RMSF of the protein in complex with ZTP or AMP. Residual fluctuations for the residues of the β-hairpin of the SARS-CoV2 N-protein NTD and loop regions are demonstrated. (B) The active site of ZTP (red) and the polar interaction (yellow dashes) with active site residues (blue) are shown. The structure of the β-hairpin is also demonstrated (cyan).
