Table 3.
Antihypercholesterolemic, 3-Hydroxy-3-methylglutaryl coenzyme A synthase, and 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibition activity prediction using Pass program
| Compound | Antihypercholesterol | HMGS-Inh | HMGR-Inh | |||
|---|---|---|---|---|---|---|
| Pa | Pi | Pa | Pi | Pa | Pi | |
| Simvastatine | 0.533 | 0.027 | 0.356 | 0.040 | 0.881 | 0.001 |
| Quercetin-3-O-rutinoside | 0.9 | 0.003 | - | - | - | - |
| Quercetin-3-O-rhamnoside | 0.804 | 0.005 | 0.225 | 0.041 | - | - |
| Quercetin-3-O-galactoside | 0.871 | 0.004 | 0.125 | 0.112 | - | - |
| Quercetin-3-O-glucoside | 0.444 | 0.030 | 0.198 | 0.032 | - | - |
| Quercetin | 0.516 | 0.020 | - | - | 0.516 | 0.020 |
| Catechin | 0.631 | 0.012 | - | - | 0.039 | 0.037 |
| Epicatechin | 0.631 | 0.012 | - | - | 0.039 | 0.037 |
| Procyanidin | 0.357 | 0.045 | - | - | - | - |
| Phloridzin | 0.722 | 0.007 | 0.163 | 0.067 | - | - |
| Chlorogenic acid | 0.423 | 0.033 | 0.198 | 0.032 | 0.042 | 0.026 |
| Pectin | 0.627 | 0.012 | 0.186 | 0.038 | - | - |
HMG-CoA: 3-hydroxy-3-methylglutaryl coenzyme A, HMGS-Inh: HMG-CoA synthase inhibition, HMGR-Inh: HMG-CoA reductase inhibition, Pa: probable activity, Pi: probable inactivity, -: Pa, Pi value is 0