Table 2.

Thymoquinone doses in different animal studies and the calculated human equivalent dose per 60kg together with the theoretical black seed oil quantity needed from different products (g/day) to provide the calculated thymoquinone quantity

Disease	Animal model	TQ dose	HED (mg)	Theoretical BSO quantity needed from different products (g/day) to provide the TQ quantity from different products (P1–P10)
				P1	P2	P3	P4	P5	P6	P7	P8	P9	P10
Hypertension and renal damage [6]	Rats	0.5 and 1 mg/kg/day; oral; for 4 weeks	4.8–9.6	3.43–6.86	0.32–0.64	0.74–1.48	0.31–0.62	1.45–2.90	0.59–1.18	0.72–1.44	0.26–0.52	6.86–13.72	0.26–0.52
Diabetic mellitus [7]	Rats	80 mg/kg; oral; for 45 days	780	557.14	52.35	120.00	50.32	236.36	95.12	116.42	41.94	1114.29	41.49
Hepatotoxicity[8]	mice	100 mg/kg; oral; single dose	486	347.14	32.62	74.77	31.35	147.27	59.27	72.54	26.13	694.29	25.85

BSO = black seed oil, TQ = thymoquinone, HED = human equivalent dose