Table 4.
Results of subgroup analysis and other endpoints.
| Factors | Categories | No.of studies | fQRS group | No-fQRS group | OR/MD(95%CI) | Model used | Heterogeneity | |
|---|---|---|---|---|---|---|---|---|
| Events/total | Events/total | I2 | p-value | |||||
| Difference endpoints of mortality | ||||||||
| In-hospital mortality | All-cause | 6 | 153/1,168 | 64/1,564 | 3.77 [2.06, 6.91] | Random | 63 | <0.0001 |
| Cardiovascular | 5 | 40/409 | 29/1,276 | 4.31 [1.75, 10.64] | Random | 58 | 0.002 | |
| Long-term mortality | All-cause | 4 | 61/807 | 38/1,427 | 4.42 [1.68, 11.60] | Random | 75 | 0.003 |
| Cardiovascular | 8 | 116/992 | 79/1,729 | 3.22 [1.79, 5.80] | Random | 66 | <0.0001 | |
| Subgroup for main endpoints | ||||||||
| In-hospital mortality | All | 11 | 185/1,612 | 92/2,607 | 3.32 [2.20, 5.01] | Random | 58 | 0.008 |
| An arbitrary ECG group | 3 | 35/493 | 2/737 | 23.32 [6.38, 85.20] | Random | 0 | 0.8 | |
| Specific time group | 8 | 150/1,119 | 90/1,870 | 2.77 [2.06, 3.72] | Random | 0 | 0.64 | |
| History of MIa | 9 | 154/1,276 | 84/2,132 | 3.30 [2.05–5.29] | Random | 48 | 0.05 | |
| First MI | 3 | 59/518 | 12/1,121 | 12.91 [3.07–54.19] | Random | 75 | 0.02 | |
| QRS duration <120 mms | 9 | 145/1,317 | 75/2,681 | 4.32 [2.57–7.26] | Random | 55 | 0.02 | |
| QRS duration Including≥120 mms | 2 | 54/386 | 19/249 | 3.74 [0.43,32.41] | Random | 61 | 0.11 | |
| Retrospective | 8 | 169/1,310 | 85/2,141 | 3.39 [2.24, 5.14] | Random | 44 | 0.08 | |
| Perspective | 3 | 30/393 | 9/789 | 7.83 [0.80, 76.36] | Random | 77 | 0.01 | |
| NSTEMIb | 1 | 2/85 | 7/348 | 1.17 [0.24, 5.75] | Random | / | / | |
| STEMIc | 8 | 157/1,449 | 68/2,451 | 4.92 [2.93, 8.28] | Random | 53 | 0.03 | |
| Long-term mortality | NSTEMI | 4 | 44/507 | 30/742 | 3.44 [2.04, 5.80] | Random | 0 | 1 |
| STEMI | 2 | 42/244 | 35/712 | 4.91 [0.82, 29.44] | Random | 91 | 0.0001 | |
| History of MI | 7 | 109/1,098 | 82/1,736 | 2.64 [1.92,3.62] | Random | 0 | 0.71 | |
| First MI | 2 | 26/187 | 16/436 | 2.77 [0.13–58.56] | Random | 94 | 0.0001 | |
| QRS duration <120 mms | 8 | 133/1,015 | 98/1,954 | 2.90 [1.71–4.93] | Random | 68 | 0.002 | |
| QRS duration Including≥120 mms | 1 | 2/270 | 0/218 | 4.07 [0.19–85.20] | Random | / | / | |
| Retrospective | 4 | 52/575 | 40/783 | 2.60 [1.64, 4.12] | Random | 0 | 0.67 | |
| Perspective | 4 | 66/417 | 43/946 | 3.24 [1.14, 9.22] | Random | 82 | 0.0007 | |
| In-hospital MACE | QRS duration Including≥120 mms | 1 | 55/217 | 9/118 | 3.32[1.70–6.48] | Random | / | / |
| QRS duration <120 mms | 4 | 103/407 | 87/868 | 2.19[1.39–3.44] | Random | 23 | 0.27 | |
| History of MI | 5 | 165/632 | 87/788 | 2.01 [1.40–2.88] | Random | 41 | 0.15 | |
| First MI | 1 | 15/91 | 20/323 | 2.66 [1.42,4.99] | Random | / | / | |
| Long-term MACE | QRS duration Including≥120 mms | 1 | 57/270 | 29/210 | 1.67 [1.02,2.72] | Random | / | / |
| QRS duration <120 mms | 6 | 262/548 | 131/802 | 4.45 [2.56,7.72] | Random | 75 | 0.001 | |
| History of MI | 5 | 210/582 | 101/527 | 3.12 [1.62–6.02] | Random | 78 | 0.001 | |
| First MI | 2 | 109/236 | 59/485 | 5.85 [3.96–8.64] | Random | 0 | 0.39 | |
| Others endpoints | ||||||||
| VT/VFd | / | 6 | 128/763 | 95/1,455 | 2.76 [1.72,4.43] | Random | 57 | 0.04 |
| Heart failure | / | 5 | 158/839 | 115/1,188 | 1.65 [1.02,2.66] | Random | 64 | 0.03 |
| TVLe | / | 7 | 327/796 | 287/1,188 | 2.14 [1.31–3.51] | Random | 79 | <0.0001 |
| LVEFf | / | 13 | −5.47 [−7.03,−3.91] | Random | 84 | <0.00001 | ||
MI myocardial infarction;
NSTEMI Non-ST-segment elevation myocardial infarction;
STEMI ST-segment elevation myocardial infarction;
VT/VF Ventricular tachycardia/ventricular fibrillation;
TVL Triple vessel lesion;
LVEF Left ventricular ejection function.