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. 2020 Oct 6;11:1027. doi: 10.3389/fphys.2020.01027

Table 4.

Results of subgroup analysis and other endpoints.

Factors Categories No.of studies fQRS group No-fQRS group OR/MD(95%CI) Model used Heterogeneity
Events/total Events/total I2 p-value
Difference endpoints of mortality
In-hospital mortality All-cause 6 153/1,168 64/1,564 3.77 [2.06, 6.91] Random 63 <0.0001
Cardiovascular 5 40/409 29/1,276 4.31 [1.75, 10.64] Random 58 0.002
Long-term mortality All-cause 4 61/807 38/1,427 4.42 [1.68, 11.60] Random 75 0.003
Cardiovascular 8 116/992 79/1,729 3.22 [1.79, 5.80] Random 66 <0.0001
Subgroup for main endpoints
In-hospital mortality All 11 185/1,612 92/2,607 3.32 [2.20, 5.01] Random 58 0.008
An arbitrary ECG group 3 35/493 2/737 23.32 [6.38, 85.20] Random 0 0.8
Specific time group 8 150/1,119 90/1,870 2.77 [2.06, 3.72] Random 0 0.64
History of MIa 9 154/1,276 84/2,132 3.30 [2.05–5.29] Random 48 0.05
First MI 3 59/518 12/1,121 12.91 [3.07–54.19] Random 75 0.02
QRS duration <120 mms 9 145/1,317 75/2,681 4.32 [2.57–7.26] Random 55 0.02
QRS duration Including≥120 mms 2 54/386 19/249 3.74 [0.43,32.41] Random 61 0.11
Retrospective 8 169/1,310 85/2,141 3.39 [2.24, 5.14] Random 44 0.08
Perspective 3 30/393 9/789 7.83 [0.80, 76.36] Random 77 0.01
NSTEMIb 1 2/85 7/348 1.17 [0.24, 5.75] Random / /
STEMIc 8 157/1,449 68/2,451 4.92 [2.93, 8.28] Random 53 0.03
Long-term mortality NSTEMI 4 44/507 30/742 3.44 [2.04, 5.80] Random 0 1
STEMI 2 42/244 35/712 4.91 [0.82, 29.44] Random 91 0.0001
History of MI 7 109/1,098 82/1,736 2.64 [1.92,3.62] Random 0 0.71
First MI 2 26/187 16/436 2.77 [0.13–58.56] Random 94 0.0001
QRS duration <120 mms 8 133/1,015 98/1,954 2.90 [1.71–4.93] Random 68 0.002
QRS duration Including≥120 mms 1 2/270 0/218 4.07 [0.19–85.20] Random / /
Retrospective 4 52/575 40/783 2.60 [1.64, 4.12] Random 0 0.67
Perspective 4 66/417 43/946 3.24 [1.14, 9.22] Random 82 0.0007
In-hospital MACE QRS duration Including≥120 mms 1 55/217 9/118 3.32[1.70–6.48] Random / /
QRS duration <120 mms 4 103/407 87/868 2.19[1.39–3.44] Random 23 0.27
History of MI 5 165/632 87/788 2.01 [1.40–2.88] Random 41 0.15
First MI 1 15/91 20/323 2.66 [1.42,4.99] Random / /
Long-term MACE QRS duration Including≥120 mms 1 57/270 29/210 1.67 [1.02,2.72] Random / /
QRS duration <120 mms 6 262/548 131/802 4.45 [2.56,7.72] Random 75 0.001
History of MI 5 210/582 101/527 3.12 [1.62–6.02] Random 78 0.001
First MI 2 109/236 59/485 5.85 [3.96–8.64] Random 0 0.39
Others endpoints
VT/VFd / 6 128/763 95/1,455 2.76 [1.72,4.43] Random 57 0.04
Heart failure / 5 158/839 115/1,188 1.65 [1.02,2.66] Random 64 0.03
TVLe / 7 327/796 287/1,188 2.14 [1.31–3.51] Random 79 <0.0001
LVEFf / 13 −5.47 [−7.03,−3.91] Random 84 <0.00001
a

MI myocardial infarction;

b

NSTEMI Non-ST-segment elevation myocardial infarction;

c

STEMI ST-segment elevation myocardial infarction;

d

VT/VF Ventricular tachycardia/ventricular fibrillation;

e

TVL Triple vessel lesion;

f

LVEF Left ventricular ejection function.