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The sketch highlights three components of a replisome that are shown to possess histone chaperone activity: the Mcm2 N-terminal histone binding domain, the Pol ε subunit Dpb3–Dpb4 heterodimer, and the N-terminal domain of Pol1. FACT, not shown here, participates in both nucleosome disassembly in front of the fork and the nucleosome reassembly following the replication fork.
