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. Author manuscript; available in PMC: 2021 Sep 30.
Published in final edited form as: Biochem J. 2020 Sep 30;477(18):3499–3525. doi: 10.1042/BCJ20200065

Figure 3. Loading onto the origin DNA of the first Mcm2–7 by ORC-Cdc6.

Figure 3.

a) A surface view of the structure of the S. cerevisiae OCCM complex (PDB 5V8F). The origin DNA is horizontal in this view but is invisible because it is inside the central channels of ORC-Cdc6 and Mcm2–7. b) Three-step loading process of the first Mcm2–7 hexamer. See text for detail.