FIGURE 1.

Proteomic analysis indicates that the CaOx crystal‐induced tubular epithelial cell (TEC) damage is closely related to the inflammation‐induced pyroptosis pathway. A, Hierarchical clustering of 104 differentially expressed proteins (DEPs) from the control and the CaOx crystal‐treated TEC samples in the absence or presence of H3 relaxin. Red represents increased expression, blue represents decreased expression, and white depicts no change in expression. n = 3, P < .05. B, The 104 DEPs were translated into significant biological properties using Gene Ontology enrichment analysis. The enriched biological behaviours were listed based on biological process, cellular component and molecular function. P < .05. C, A protein node complex composed of 22 significantly detected or inflammation‐related proteins, as a protein‐protein interaction network, was constructed by STRING online database. Only significant correlations are shown (P < .05)