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. 2020 Sep 10;53(10):e12895. doi: 10.1111/cpr.12895

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© 2020 The Authors. Cell Proliferation published by John Wiley & Sons Ltd

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Inhibiting checkpoint kinase 1 (CHK1) activity affects development of early mouse embryos. A, The rates of 2‐cell embryos in the control and 2.5 and 5 μmol/L treatment group embryos. *Significant difference (P < .05). B, The cell cycle progression of the first cleavage after inhibiting CHK1 in mouse embryos. Bar = 100 μm. C, The rates of 2‐cell embryos at different time points during the first cleavage in mouse embryos. *Significant difference (P < .05) **Significant difference (P < .01). D, The developmental rate of early embryos in the treatment group at each stage decreased significantly compared with that in the control group. Bar = 100 μm. E, The developmental rate of early embryos in the control and treatment groups at each stage. *Significant difference (P < .05) **Significant difference (P < .01)