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. 2020 Sep 10;53(10):e12895. doi: 10.1111/cpr.12895

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© 2020 The Authors. Cell Proliferation published by John Wiley & Sons Ltd

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Inhibiting checkpoint kinase 1 (CHK1) induces apoptosis during early embryonic development in mice. A, The control and CHK1‐inhibited embryos at the 2‐cell stage were stained with Annexin‐V (green). Bar = 30 μm. B, The percentages of cells in early apoptosis in the mouse embryo treatment and control groups. **Significant difference (P < .01). C, The expression of apoptosis‐related genes in the treatment and control groups. **Significant difference (P < .01). *Significant difference (P < .05). D, Bax expression in embryos from the control and treatment groups was determined by immunoblotting. E, Band intensity analysis of Bax in the two groups. **Significant difference (P < .01)