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. 2020 Oct 19;8(1):e001278. doi: 10.1136/bmjdrc-2020-001278

Figure 6.

Figure 6

Attenuation of pericyte loss in the diabetic retina by aflibercept. (A) Representative images of PDGFR-β staining for retinal pericytes. Pericyte numbers were decreased in mice with diabetes, and this decrease was attenuated by aflibercept treatment. Original magnification: ×200; scale bar: 200 µm. (B) Quantification of the number of pericytes (CTL, n=8; DM, n=15; DM-aflibercept, n=9; ##p<0.001). (C) Immunostaining of retinal flat mounts with antibodies for CD31. Endothelial cells were intact in mice with diabetes and showed no significant changes in aflibercept treatment. Original magnification: ×200; scale bar: 200 µm. (D) Quantitative data of the number of endothelial cells (CTL, n=3; DM, n=3; DM-aflibercept, n=4; p>0.05, N.S.). CTL, control; DM, diabetes mellitus; N.S., not significant; PDGFR-β, platelet-derived growth factor receptor-β.