Table 3.

Complications and activity markers with or without early elevation of sC5b-9 until day 28.

	sC5b-9 elevation from baseline to day 28 (n = 37)	No change or decrease of sC5b-9 from baseline to day 28 (n = 29)	P-value
Engraftment day	23 (17–27)	18 (13–24.5)	0.022
TA-TMA before day 100	10 (27)	0 (0)	0.002
TA-TMA before day 28	3 (8.1)	0 (0)
Acute GVHD before day 100	7 (18.9)	6 (20.7)	1
Acute GVHD before day 28	3 (8.1)	2 (6.9)	1
Viral reactivation before day 100	18 (48.6)	14 (48.3)	1
Viral reactivation before day 28	8 (21.6)	7 (24.1)	0.31
Fever on day 28	3 (8.1)	1 (3.5)	0.62
Bloodstream infection	11 (29.7)	8 (27.6)	1
Transplant failure before 100 days	3 (8.1)	1 (3.5)	0.62
Diagnostic parameters for TA-TMA
Elevated LDH until day 28	5 (13.5)	5 (17.2)	0.74
Elevated LDH until day 100	24 (64.9)	13 (44.8)	0.14
New onset anemia until day 28	1 (2.7)	2 (6.9)	0.58
New onset anemia until day 100	18 (48.6)	13 (44.8)	0.8
New onset thrombocytopenia until day 28	0	0
New onset thrombocytopenia until day 100	15 (40.5)	10 (34.5)	0.8
Low haptoglobin until day 28	10 (27)	8 (27.6)	1
Low haptoglobin until day 100	13 (35.1)	12 (41.4)	0.62
Fragmentocytes until day 28	13 (35.1)	12 (41.4)	0.62
Fragmentocytes until day 100	20 (54)	15 (51.7)	1
Proteinuria until day 28	6 (16.2)	5 (17.2)	1
Proteinuria until day 100	13 (35.1)	5 (17.2)	0.16
Hypertension until day 28	17 (45.9)	7 (24.1)	0.078
Hypertension until day 100	22 (59.5)	8 (27.6)	0.013
None of the seven	11 (29.7)	4 (13.8)
One of the seven	12 (32.4)	13 (44.8)	0.28
At least two of the seven until day 28	14 (37.8)	12 (41.4)

Data presented are median (interquartile range) or n (%). P-values were obtained by Fisher's exact test.