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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2020 Aug 4;13(9):e008638. doi: 10.1161/CIRCEP.120.008638

Figure 7:

Figure 7:

Proposed arrhythmia mechanism for KCNJ2 mutation: Adrenergic loss of IK1 causes a critical change in membrane voltage that decreases repolarization reserve and drives the development of phase 3 EAD.