Figure 1.

Sources of inter-individual variability in the neoantigen presentation process. A summary of the MHC-I antigen presentation pathway is shown. The integrity of these processes can be interrogated using sequencing, which also provides an unbiased assessment of many features leading to inter-individual variability in immune responses. The tumor mutational repertoire, the breadth of the immunopeptidome and the composition of the immune repertoire are sources of inter-individual variability that can be interrogated. Refinement of these platforms is already paving the way towards the individualization of cancer care.