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. 2020 Oct 19;9(1):1830513. doi: 10.1080/2162402X.2020.1830513

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Differential transcriptomic analysis of B cells between the FVB/NJ and MMTV-PyMT samples

(A) B cells (colored in yellow) in tSNE plot. (B) Bar chart representation of the results of GSVA based on hallmark gene sets. The value in the bottom represents the difference between the enrichment scores (ESs) of a gene set in the FVB/NJ and in MMTV-PyMT samples, and a positve value represents upregulation of a gene set/pathway in PyMT sample. Bar colored in gray represents q value > 0.1. (C) Violin plots showing the distribution of gene expression levels of top 10 upregulated genes in B cells of MMTV-PyMT relative to FBB/NJ samples. (D) Vocano plots showing differential expression of selected B cell marker genes between FVB/NJ and MMTV-PyMT samples. (E) Flowcytometric analysis showing the reduction of the percentages of B cells in MMTV-PyMT than in FVB/NJ sample.