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. 2020 Oct 15;13:10475–10487. doi: 10.2147/OTT.S253758

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© 2020 Sun et al.

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CDC20 is a downstream gene of MDM2-P53 signaling pathway in DLBCL. (A and B) RT-qPCR detected the mRNA levels of TP53 and CDC20 in MDM2 KD and Ctrl OCI-Ly3 cells. (C and D) RT-qPCR validation of TP53 and CDC20 mRNA levels in MDM2 KD and Ctrl OCI-Ly10 cells. (E) MDM2, wtp53 and CDC20 protein expressions were analyzed by immunofluorescence staining in Ctrl and MDM2 KD OCI-Ly3 cell (× 630, scale bar, 10μm). **P < 0.01; ***P < 0.001.

Abbreviations: DLBCL, diffuse large B-cell lymphoma; KD, knocked down; Ctrl, control; DAPI, 4ʹ,6-diamidino-2-phenylindole.