Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 15;13:10475–10487. doi: 10.2147/OTT.S253758

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Sun et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

CDC20 expression was elevated in DLBCL, and overexpression of CDC20 could be an unfavorable prognostic factor. (A) Venn diagram showing 74 upregulated genes in GSE32018 and GSE56315 datasets. CDC20 was up-regulated in these two GEO datasets. (B and C) Scatterplot indicated that CDC20 mRNA level was elevated in both GSE32018 and GSE56315 datasets. (D) TCGA DLBCL confirmed that CDC20 was overexpressed in DLBCL. (E and F) RT-qPCR and Western blot assays detected CDC20 expression in DLBCL cells and PBMCs. (G) IHC of CDC20 expression in one normal and two representative cases of 97 DLBCL tissues (× 200, scale bar, 50μm). (H) Kaplan–Meier OS analysis of 97 DLBCL patients with different CDC20 protein expression levels. (I) Association between CDC20 expression level and OS in DLBCL based on GSE31312 (n=470). Kaplan-Meier survival curves were generated by using R2 (http://r2.amc.nl). *P < 0.05, **P < 0.01, ***P < 0.001.

Abbreviations: DLBCL, diffuse large B-cell lymphoma; TCGA, The Cancer Genome Atlas; num, number; T, tumor; N, normal; PBMCs, peripheral blood mononuclear cells; IHC, immunohistochemistry; OS, overall survival.